Summary of Modern Studies on Yuanhu Zhitong (Analgesic Formula™) Capsule

 

Chinese Use: Analgetic, superficial gastrits, peptic ulcer.

 

Modern studies on pharmacodynamics reveal that this product yields actions of analgesia, sedation, hypnosis, anti-peptic ulcer, inhibition gastric.

1.      Analgesic: By electric shock hitting at the tail of mice, it is proved that oral administration of Rhizoma Corydalis yields analgesic action, with its titre equals to 1/10 that of opium, the action lasting for 2 hrs. Radix Angelica Dahurica yields similar action.

2.      Sedation, hypnosis: Rhizoma Corydalis contains Corydaline B. which yields sedation and hypnotic actions. Repeated administration may lead to drug-resistance.

3.      Anti-peptic ulcer, inhibition of gastric secretion: the Corydaline it contains yield marked anti ulcer action due to pyloric ligation, responsive ulcer due to water immersion, histamin and acetic acid. To such rat, it markedly inhibits the gastric secretion and acidity.

4.      Others: Radix Corydalis increases the coronary blood flow in rabbit heart in vitro. It decreases the heart rate in cat, lowers its blood pressure, increases coronary blood flow, markedly protects mice under conventional pressure or anoxic state. In “mountain climbing” experiment, it elevates the survival rate, prolongs survival time. It also yields some protection on necrotic heart muscle in rat induced by isoprenaline. Radix Angelica Dahurica solution yields inhibition on E. coli, dysenteric bacilli, Bacilli of typhoid and paratyphoid fever, pseudomonas aeruginosa, proteus, hemophilus influenzae.

 

Clinically, his product was applied in many non-surgical pain, superficial gastritis, peptic ulcer.

1.      Anagelsia: This product is an analgesic tablet. It was applied in many spasmodic pain of visceral and non-spasmodic pain. Dull pain in chest, abdomen, stomachache, headache, insomnia, pain in lower limb, menstrual pain, but it is not so effective for surgical pain.

2.      Superficial gastritis: 127 cases were treated with a dose of 6 tablets, t.i.d. (smaller dose for children), with 5 days as a therapeutic course. 92 case (74.45%) were cured with 1 course; 28 cases (22%), cured by 1~2 courses; 7 cases (5.55%), non-effective, the total effective rate being 94.45%.

3.      Peptic ulcer: Corydaloid was applied for gastric or duodenal ulcers. 461 cases were treated. 76.1% were effective. After medication, gastric secretion was lessened, activity of pepsin lowered, pH elevated gradually, demonstrating its satisfactory effect on peptic ulcer.

Others: 200 cases of coronary heart disease were treated with rather satisfactory results. Corydalin was also prepared as injection for local anesthesia, the results were also satisfactory.

 

Excerpt from A Guide to TCM Products, China Academy of Traditional Chinese Medicine, 2003

 

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any diseases.