Summary of Modern Studies on Ganweishu (Stomach Peace™) Capsule

 

Chinese Use: Chronic gastritis, endogastritis.

 

Modern studies on pharmacodynamics reveal that this product yields actions of anti-convulsion, anti-virus, inducing interferon, sedation, lowering of body temperature, increasing blood pressure, anti-shock, anti-arrhythmia, cardiotonic, promoting cerebral blood flow, anti-platelet aggregation, inhibition of in vitro thrombosis, protecting the liver, detoxication, anti-inflammation and analgesia.

1.      Anti-convulsion: For anti-ulcer, it is 100%. The water extract alcohol precipitated form inhibits the contraction of intestinal smooth muscle, slows down the frequency and shortens its amplitude. It also antagonizes the spasmodic contraction of intestine induced by acetylcholine and barium chloride. Sini Powder is capable of anti-experimental ulcer. When rat is fasting for 3 hours, ether anesthesia, ligation of pylorus are administered, followed by infusion of alcohol extract of Sini powder into the duodenum, 8ml/kg, then the animal continues the fasting and interruption of water for another 12 hrs. Kill the rat and let out its blood, and observe the ulcer in its stomach. Results show that the index of ulcer in the experimental group and difference of its average number are significantly different from that of the control group.

2.      Anti-virus, inducing interferon: Decoction of this product reveals certain anti VSV virus in cellular culture, manifesting direct killing of virus, inhibition of viral proliferation, and protection on virus attacking cell. Sini Powder also promotes NDN induced interferon, with direct induction of its production.

3.      Sedation, lowering of body temperature: 10% Sini Powder 0.1ml/10g and 2.5% Decoction of Fructus Aurantii immaturus 0.1ml/10g injected intraperitoneally all strengthens the hypnotic action of sodium pentobarbital, indicating that Sini-powder yields sedative action on CNS. In addition, Decoction of Sini-powder is perfused into the stomach 20g/kg at 20ºC room temperature. It is found that it lowers the normal body temperature in mice.

4.      Liver protection, detoxication, anti-inflammation, analgesia: single drug Radix Bupleura or Radix Glycyrrhizae yields anti-liver injury action. The latter also has detoxication action. Both, and Radix Paeonia alba yield anti-inflammation effect. Radix Bupleuri is also an analgesic.

 

Toxicological studies: The LD₅₀ of Ganweishu capsule, when injected intraperitoneally is 122.9g/kg in mice; for i.v., it is 22.4g/kg. Sini Powder Decoction 15g/kg administered to rat, q.d. for 20 days, show no changes in its body weight, GPT, and BUN.

 

Clinically, this product was applied in gastritis, peptic ulcer, abdominal pain, hepatitis, cholecystitis, costal neuralgia, kidney stone, cystitis, epilepsy, neurasthenia, anti-shock, anti-arrhythmia, mastitis, otitis media, costal chondritis, obstruction of Fallopian tube, chronic annexitis, hyperthyroidism, and impotence.

1.      Stomach disorders: 65 cases of peptic ulcer were treated. Results showed that 46 cases were markedly effective; 14 ameliorated; 5 ineffective, the total effective rate being 92.3%; 9 cases of bleeding in upper digestive tract of the type of stomach invaded by liver qi were treated mainly with this product with satisfactory results. 54 cases of bile regurgitation gastritis were treated with this product plus additives, 34 cases were markedly effective; 6 cases, ameliorated; 5 cases, ineffective; the total effective rate being 90.7%. 52 cases of epigastric pain were treated with Sijunzi Decoction and Sini Powder with additives, 49 were cured; 2 cases, markedly effective; the total effective rate being 98.1%. Acute and chronic gastritis (stomachache) treated with modified Sini Powder with satisfactory results. 42 cases of chronic gastritis were treated with Sini Powder plus Xiaoxianxiong Decoction, 23 cases were cured; 16 cases ameliorated; 3 cases ineffective.

2.      Abdominal pain: 49 cases of acute upper abdominal pain were treated with Sini Powder with additives. 40 cases were markedly effective; 7, effective; 2, ineffective, the total effective rate being 95.91%. This product also treats stubborn abdominal pain, it also is effective for infantile abdominal pain and unknown cause abdominal pain.

3.      Intestinal disorders: 31 cases of chronic ulcerative colitis were treated with this product with additives with a clinical total effective rate of 93.5%.

4.      Hepatitis: Patients with manifestations of qi stagnation and liver stagnation, costal pain can be treated with this product. 75 cases of chronic persisting hepatitis were treated. Among them, 48 cases ere persisting type, 29 cases were cured; 9 cases, clinically cured; 7 cases, markedly effective; 3 cases, non-effective; the effective rate being 90%. 27 cases were chronic hepatitis, 17 were cured; 6 cases, clinically cured; 3 cases markedly effective; 20 cases of acute icteric hepatitis were treated with Sini Powder plus modified Wuling powder.

 

Excerpt from A Guide to TCM Products, China Academy of Traditional Chinese Medicine, 2003

 

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease