Summary of Modern Studies on Huoxiang Zhengqi (SummerEase™) Capsule

Chinese Use: Cold, acute gastroenteritis, acute or chronic colonitis, urticaria, acidosis, ringworm of the body, dermatitis.

Modern studies on pharmacodynamics reveal that this product yields effects of anti-convulsion, analgesia, bacteriostatic, promotion of intestine peristalsis, promotion of intestinal absorption, antiemesis, and promotion of cellular immunity.

• Anti-convulsion: It reveals marked anti-convulsive effect. The normal rate of inhibition for rabbit intestine in vitro is 73.8% when the concentration is 8.55×10-4g/ml. Meantime, it also inhibits its convulsion induced by acetylcholine, barium-chloride, the rate of convulsion are 61.8% and 68.3% respectively. Low concentration sample yields biphasic regulation, while high concentration, inhibition. It also inhibits acetylcholine.
• Analgesia: Marked analgesic effect for pain induced by acetic acid (torsion method). Capsule form is antagonistic to pain induced by potassium antimony tartrate. For pain induced by heat plate method, this product increases pain threshold to 10% in 90 minutes.
• Bacteriostasis: It reveals bacteriostatic action on 8 kinds of bacteria including lutea-sarcina, especially effective for sarcina and staphylococcus aureas.
• Promotion of peristalsis of stomach and intestine: Marked effect on the transmission of digestive tract in mice is revealed with solution and capsule forms. Experimental group reveals milder promoting velocity of peristalsis than the control-group, demonstrating its inhibition action.
• Promotion of absorption of digestive tract: Diarrhea mice model reveal increase of absorption of glucose and water in the liver and blood, thus, absorption of the digestive tract after diarrhea has been checked and restored.
• Antiemesis: Infuse pigeon with 11.4% solution 20ml/kg. After 5 minutes, 1.5% CuSO4 solution in 20ml/kg dose is infused. As compared with the control group, there is significant difference in the latent period of vomiting and frequency of vomiting, demonstrating that this product doesn’t cause vomiting, but yields antiemetic action.
• Strengthening cellular immunity: Mice model of diarrhea induced by MgSO4 are treated with this product. The result reveals increase of index of peripheral lymphocytic infiltration of 3H-TdR, but it is lower in the control group than in the normal (no diarrhea) groups. The experimental group is close to normal groups, demonstrating that this product increase the immunity in mice, and promotes the healing of intestine segment after injury.

Studies on Toxicology: 53.2% of this product in the dose of 25ml/kg (583 times higher than man’s dosage), twice a day for 7 days. No fatal animal reported.

Clinically this product is commonly used in common cold, acute gastro-enteritis, acute and chronic colitis, urticaria, tinea and dermatitis, acidosis.

• Common cold: For those of external wind-cold, with internal block of phlegmatic dampness, cold, chill, headache, stuffy chest, painful epigastrium, vomiting and diarrhea, this product is commonly used. For flu of the type dampness stagnated in the spleen, the effect is satisfactory. 34 cases of infantile summer cold, solution of this product yielded good results. Of the 20 cases of fever in cold, 5 cases were markedly effective, 13 effective, 2 cases non-effective.
• Gastro-intestinal diseases: 112 cases of gastroenteritis were all cured with modified product. For gastro-intestinal diseases of the type of internal block of damp-turbidity, spleen disturbed by cold dampness resulting in malfunction of the spleen, manifesting stuffy chest, abdominal distention, diarrhea, with white thick fur and soft pulse, the results were satisfactory of the 96 cases of infantile autumn diarrhea, 8 cases had diarrhea arrested after 12~48 hrs; 24 cases, after 48~72 hrs., 85 cases were cured, 6 cases effective, 5 cases non-effective, the cured rate being 88.5%, total effective rate, 94.7%. The time for cure is averagely 7 days. For infantile dyspepsia, 63 cases were treated, with 24 cases diarrhea arrested in 1 day; 21 cases, in 2 days; 12 cases, in 3 days; 4 cases, in 5 days; 2 cases ineffective.

Urticaria: 32 cases were treated. The maximal dosage of administration was 35; minimal dose being 3 doses, all were cured.

Excerpt from A Guide to TCM Products, China Academy of Traditional Chinese Medicine, 2003

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any diseases.